NADPH oxidases and atherosclerosis: unraveling the details
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چکیده
منابع مشابه
NADPH oxidases and atherosclerosis: unraveling the details.
NADPH OXIDASE (NOX)-mediated generation of reactive oxygen species (ROS) was first described in phagocytic cells, and for many years it was assumed that the primary role of NADPH oxidase activation was bacteriocidal; phagocytes generated a burst of ROS following activation. More recently, it has become clear that not only do multiple homologous NADPH oxidase subunits exist but that the expressi...
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Atherosclerosis is a complex disease that remains a leading cause of death and disability. The formation of vascular plaques arises from the interaction of dyslipidemia with the altered function of blood vessels and immune cells. The exact cause of atherosclerosis is not known, but from the 1950s onward, oxidative modifications of lipids and proteins were detected in vascular lesions, and the d...
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Proton channels allow cells to extrude excess acid with a high efficiency and therefore are one of the important homeostatic mechanisms that maintain the intracellular pH in a range compatible with life. Proton currents are highly expressed in phagocytes where they are thought to contribute to charge and pH compensation during NADPH oxidase activation. By analogy with the cytochrome C oxidase o...
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and Duox in the respiratory epithelium. The location of these ROS-generating enzymes in the barrier tissues has prompted the expectation of their participation in host defense against invading pathogens in these tissues. Indeed, recent studies have begun to support this expectation, demonstrating roles in bacterial killing, cytokine production, apoptosis, gene expression and signaling, includin...
متن کاملNADPH Oxidases in Innate Immunity
and Duox in the respiratory epithelium. The location of these ROS-generating enzymes in the barrier tissues has prompted the expectation of their participation in host defense against invading pathogens in these tissues. Indeed, recent studies have begun to support this expectation, demonstrating roles in bacterial killing, cytokine production, apoptosis, gene expression and signaling, includin...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2010
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.01020.2009